Parsely, celery and chamomile tea are the most common sources of the substance apigenin. You are in the right track if you love those. On the other hand, eating lots of fruits and vegetables is going to give you apigenin.
What is apigenin and why I need it?
According to Wikipedia: Apigenin (4’,5,7-trihydroxyflavone), is found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool.
Andrea Doseff, Erich Grotewold and party of Ohio State University found an exciting feature of apigenin. It is an awesome cancer fighter. It has the ability to deter cancer cells’s persistent ability to survive and direct it to its programmed death and become more sensitive to chemotherapeutic drug.
Cancer cells have a unique way of survival. The substance apigenin prevents this by making them die on regular cycle.
They established that apigenin had relationships with proteins that have three specific functions. Among the most important was a protein called hnRNPA2. It influences the activity of messenger RNA, or mRNA, which contains the instructions needed to produce a specific protein. The production of mRNA results from the splicing, or modification, of RNA that occurs as part of gene activation. The nature of the splice ultimately influences which protein instructions the mRNA contains.
Abnormal splicing is the culprit in an estimated 80 percent of all cancers. In cancer cells, two types of splicing occur when only one would take place in a normal cell – a trick on the cancer cells’ part to keep them alive and reproducing.
The researchers observed that apigenin’s connection to the hnRNPA2 protein restored this single-splice characteristic to breast cancer cells, suggesting that when splicing is normal, cells die in a programmed way, or become more sensitive to chemotherapeutic drugs.
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