Guava / Bayabas Leaves for Diabetic Treatment

Here are excerpts from few scientific studies regarding bayabas leaves and diabetes treatment. All of them showed positive and promising results. However, they may not be conclusively applicable to humans. Experiments used rats as test subjects.

1) Study results support the hypothesis that Psidium guava could play a role in the management of diabetes and the prevention of vascular complications in STZ-induced diabetic rats.

2) The experiments provided evidence to support the antihyperglycemic effect of guava leaf extract and the health function of guava leaves against type 2 diabetes.

3) Data indicated that Guava Leaf extracts improved glucose metabolism and insulin sensitivity in the skeletal muscles of rats by modulating the insulin-related signaling.

4) Study revealed that M. indica water extract and P. guajava water extract either used individually or in combination have strong hypoglycemic and anti-diabetic effects as compared with glibenclamide.

5) The study demonstrates the ability of various extracts of P.guajava to inhibit glucose diffusion using an in vitro model of glucose absorption. In particular, methanol and aqueous extracts represent potential inhibitory of glucose diffusion supplements that may be useful for allowing flexibility in meal planning in type 2 diabetes.

6) We found that the administration of PE to rats with 8 weeks of uncontrolled diabetes reverses the DM-induced harmful effects on vascular smooth muscle.

7) Conversely, guava bud extract displayed significant insulin-mimetic and
potentiating activity.


1) Effect of the administration of Psidium guava leaves on blood glucose, lipid profiles and sensitivity of the vascular mesenteric bed to Phenylephrine in streptozotocin-induced diabetic rats
– Abdol Hassan Mansoori Bahrani1, Habib Zaheri, Nepton Soltani, Fatemeh Kharazmi, Mansoor Keshavarz, Mohammad Kamalinajad
– Journal of Diabetes Mellitus, Vol.2, No.1, 138-145 (2012), doi:10.4236/jdm.2012.21023

2) Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats.
– Shen SC, Cheng FC, Wu NJ.

3) Guava leaf extracts promote glucose metabolism in SHRSP.Z-Leprfa/Izm rats by improving insulin resistance in skeletal muscle
– Xiangyu Guo, Hisae Yoshitomi, Ming Gao, Lingling Qin, Ying Duan, Wen Sun, Tunhai Xu, Peifeng Xie, Jingxin Zhou, Liansha Huang and Tonghua Liu

4) Biochemical changes in experimental diabetes before and after treatment with mangifera indica and psidium guava extracts
– Sayed M. Rawi, Iman M. Mourad, Dawlat A.Sayed
– Int J Pharm Biomed Sci 2011, 2(2), 29-41, ISSN No: 0976-5263

5) In vitro antidiabetic activity of psidium guajava leaves extracts
– Sabjan Khaleel Basha, Vinoji Sugantha Kumari
– journal

6) Polyphenolics-Rich Psidium guajava Budding Leaf Extract CanReverse Diabetes-Induced Functional Impairment of Cavernosal Smooth Muscle Relaxation in Rats
– Chia-Hung Liu, Chiung-Chi Peng, Chiung-Huei Peng, Chiu-Lan Hsieh, Kuan-Chou Chen and Robert Y. Peng

7) Consumption of guava (Psidium guajava L) and noni (Morinda citrifolia L) may protect betel quid-chewing
– Patrick L Owen, Louis C Martineau, Dayna Caves, Pierre S Haddad, Teatulohi Matainaho and Timothy Johns

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